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Cardiac Repair: Some of the recent discoveries that feature stem cell
replacement and muscle regeneration strategies for repairing the
damaged heart. Researchers are working toward using stem cells to
replace damaged heart cells and literally restore cardiac function. Stems
cells have the ability to act as a cardiac repair system, rebuilding and
restoring healthy functions and replenishing other cells in heart as long as the
organism is alive. The difficulty in regenerating damaged myocardial tissue has
led researchers to explore the application of embryonic and adult-derived stem
cells for cardiac repair.
The Cardiac Repair mechanism by which stem cells promote cardiac
repair remains controversial, and it is likely that the cells regenerate
myocardium through several pathways. Initially, scientists believed that
transplanted cells differentiated into cardiac cells, blood vessels, or
other cells damaged by CVD. However, this model has been recently supplanted by
the idea that transplanted stem cells release growth factors and other molecules
that promote blood vessel formation (angiogenesis) or stimulate “resident”
cardiac stem cells to repair damage.
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